|
Symbol Name ID |
Sod1
superoxide dismutase 1, soluble MGI:98351 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Aganglionic megacolon |
Dysphagia |
Pseudobulbar paralysis |
Photophobia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Degeneration of anterior horn cells |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Degeneration of the lateral corticospinal tracts |
Alzheimer disease |
Neurodegeneration |
Bradykinesia |
Fasciculations |
Tremor |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Panic attack |
Hallucinations |
Atypical behavior |
Apathy |
Reduced social reciprocity |
Polydipsia |
Polyphagia |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Short attention span |
Intellectual disability |
Sleep abnormality |
Insomnia |
Sleep apnea |
Hyperreflexia |
Jaw hyperreflexia |
Dyskinesia |
Dystonia |
Gait disturbance |
Gait imbalance |
Postural instability |
Developmental regression |
Specific learning disability |
Seizure |
Impaired pain sensation |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with SOD1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis type 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Down syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| retinitis pigmentosa | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| type 1 diabetes mellitus |
| Mouse Phenotypes | nervous system phenotype |
cochlear inner hair cell degeneration |
cochlear outer hair cell degeneration |
cochlear hair cell degeneration |
microgliosis |
abnormal hypoglossal nucleus morphology |
abnormal oculomotor nucleus morphology |
abnormal facial motor nucleus morphology |
abnormal trigeminal motor nucleus morphology |
astrocytosis |
abnormal motor neuron innervation pattern |
abnormal corticospinal tract morphology |
decreased motor neuron number |
motor neuron degeneration |
decreased retina ganglion cell number |
short retina rod cell outer segment |
retina photoreceptor degeneration |
cochlear ganglion degeneration |
abnormal cranial nerve morphology |
abnormal cochlear nerve morphology |
abnormal spinal cord dorsal horn morphology |
abnormal spinal cord ventral horn morphology |
neurodegeneration |
abnormal neuron physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||
| Sod1m1H/Sod1m1H | |||||||||||||||||||||||||
| Sod1tm1Cep/Sod1tm1Cep | |||||||||||||||||||||||||
| Sod1tm1Leb/Sod1tm1Leb | |||||||||||||||||||||||||
| Sod1m1H/Sod1+ | |||||||||||||||||||||||||
| Sod1tm1Cep/Sod1+ | |||||||||||||||||||||||||
| Sod1tm1Leb/Sod1+ | |||||||||||||||||||||||||
| Tg(Sod1*G86R)M1Jwg/0 | |||||||||||||||||||||||||
| Tg(SOD1*G86R)M3Jwg/0 | |||||||||||||||||||||||||
| Sod1tm1Svb/Sod1tm1Svb Tg(ACTA1-cre)79Jme/0 (conditional) |
* | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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